Often, a secondary design will reveal itself as the blocks are stitched in place.
Straight Set, Block-to-Block Variation
Change the direction of the asymmetrical blocks in a block-to-block layout, and a new design will emerge.
Straight Set with Setting Squares
For another look, lay out blocks with alternating setting (plain) squares in straight horizontal and vertical rows.
Straight Set with Alternate Blocks
A similar, but more complex, look is achieved when you replace the plain setting squares with an alternate quilt block.
Straight Set with Continuous Sashing
Lay out blocks in straight horizontal and vertical rows with strips for sashing between.
Straight Set with Sashing Strips and Squares
Lay out blocks in straight horizontal and vertical rows with alternating strips and squares for sashing between the blocks. Put sashing between every block, or follow the example shown here, in which sashing surrounds each group of four blocks.